Systemic infection-
Neonate < 1 wk and < 2 kg: 50 mg/kg IM, IV qd divided 12 h.
Neonate < 1 wk and > 2 kg or > 1 wk and < 2 kg: 75 mg/kg IM, IV qd in divided doses q 8 h.
Neonate > 1 wk and > 2 kg: 100 mg/kg IM, IV qd in divided doses q 6 h.
Upper respiratory, skin, skin-structure infection-
Infant, child > 1 month and < 40 kg:50 mg/kg PO, IM, IV qd in divided doses q 6 h.
Child > 40 kg, adult: 500 mg PO q 4-6 h; or 250-500 mg IM, IV q 4-6 h. In adult with CrCl < 10 ml/min, 1 gram IM, IV q 4-6 h.
Severe lower respiratory infection, disseminated infection, osteomyelitis-
Infant, child > age 1 month and < 40 kg: 100-200 mg/kg IM, IV qd in divided doses q 4-6 h.
Child > 40 kg, adult: 1 gram IM, IV q 4-6 h. In adult with CrCl < 10 ml/min, 1 gram IM, IV q 4-6 h. |